Sibutramine is the most popular substance for appetite suppression, but there is one but. It is that you can not buy this drug without a prescription. The main effects of sibutramine are: inhibition of presynaptic reuptake of monoaminergic neurotransmitters in the central nervous system and suppression of the appetite itself. Then the second significant effect is: activation of anorexigenic secretion and a decrease in the secretion of oryxigenic neuropeptides and also the drug increases energy consumption and activates the sympathetic effects of the peripheral nervous system. In 1997, sibutramine, was approved as a substance to reduce the body weight of the FDA.


The dose of sibutramine is 10 mg per day, taking is in the morning. If this dosage is not enough, then for a few days you can raise to 15, but no more. There are rumors that with large doses of sibutramine, it becomes a drug. But all this is a lie, since there are no dependencies on the drug and it does not increase the release of dopamine from the synapses. But still, do not exceed the recommended dose, as this can cause a number of side effects and a kind of complication. It is best to combine sibutramine with exercise and a low-calorie diet. Usually the course is 6-12 months, for this period you will see the result yourself.

Side effects

The main problem is the occurrence of abnormalities in the cardiovascular system. Which is not very good. Very often it happens. Increases blood pressure and increases heart rate. Also, there may be side effects such as: nausea and vomiting, indigestion, insomnia, algomenorrhea, joint and muscle pain, as well as visual impairment and impairment.