Testosterone propionate

Testosterone propionate is an oil injection of testosterone, testosterone added to the oil with a 17-beta hydroxyl group-propionate ether androsten-3-one, 17β-ol, androgen, the half-life is 24 to 48 hours, the chemical structure of C3H6O2. Propionate is the fastest preparation of relatively esters, cypionate or enanthate. The nominal concentration of testosterone in such ether leaves 83 mg per 100 mg, therefore, the remaining 17 mg is the mass of the propionate ester itself. Ether propionate is poorly tolerated, as it causes irritation at the injection site. In this regard, some pharmaceutical companies have introduced the fatty acid ester (ethyl oleate) into the main formulation, which is obtained due to the condensation of oleic acid and ethanol. In this regard, irritation at the injection site is almost not manifested.

Historical reference

The first company that started producing testosterone propionate back in the late thirties of the last century was Schering. Thanks to this company, testosterone ester, as the first and only one of its kind, immediately won a leading position in the global pharmaceutical market. The peak of its popularity lasted until the end of the fifties, but at the moment there is not a single drug capable of eclipsing its popularity among the male population of the world. And the ability of testosterone propionate to make a strong half of humanity even more manly in all senses of the word, provides testosterone propionate manufacturers with orders for many years to come.

Pharmacological action (according to the manufacturer)

Testosterone propionate has a specific androgenic effect, namely: stimulation of the development and function of the external genital organs, effects on the prostate gland, seminal vesicles, and the effect on the manifestation of secondary sexual characteristics in men (voice, hair). Testosterone propionate takes an active part in the processes of constitution of the body, as well as sexual behavior in men, leads to the activity of libido and potency, stimulates the processes of spermatogenesis. The drug can significantly reduce the amount of synthesized luteotropic and follicle-stimulating hormones. Recall that testosterone refers to antagonists of female sex hormones – estrogens, and therefore may have antitumor effect in the presence of breast tumors in women.

Testosterone propionate can also have an anabolic effect, which manifests itself as: stimulation of protein synthesis processes; reduction of fatty deposits; the retention in the body of substances necessary for the synthesis processes, such as the protein of potassium, phosphorus, sulfur; increasing the fixation of calcium directly in the bones, as well as the growth of muscle mass. If you eat foods that contain large amounts of protein when taking the drug, the process of producing erythropoietin will be stimulated.

Steroid profile of testosterone propionate

  • Testosterone propionate is active for 24 to 48 hours
  • By classification: an anabolic / androgenic steroid
  • Method of application: injections
  • Dosage for men is 100 to 200 mg, taken every other day. For women (pros) it is recommended to take the drug at a dose of 25-50 mg / day every other day
  • When taking the drug in large doses or in case a person has a predisposition, there may be an acne
  • If compared with long esters of testosterone, when taking testosterone propionate there will be a slight water retention
  • When the dosage is exceeded, it is possible to raise the blood pressure
  • Toxicity to the liver: low
  • Aromatase: high
  • The level of synthesis of natural testosterone decreases
  • There is a process of converting dehydrotestosterone
  • Anabolic activity (100%) \ Androgenic activity (100%).
  • In human blood, according to the latest data, the drug is detected during a doping test up to four weeks.

Effects of taking testosterone propionate:

  1. The growth of muscle mass (since the time of action of the drug is not long-lasting, the effect, expressed in the growth of muscle mass, will not be clearly expressed, however, the acquired mass will differ by a small percentage of the water content)
  2. Getting rid of excess fat
  3. Muscles will become more rigid and embossed
  4. Power indicators will increase relatively fast
  5. During the course of the course, there will be an increase in libido
  6. The risk associated with the occurrence of coronary and coronary heart disease will be significantly reduced


For women:

Propionate is the only ether, the use of which is less risky for women. Dosage should be from 25 to 50 mg, but do not forget that any testosterone testosterone is not recommended for women without special indications to this.

For men:

Men who are actively involved in sports are recommended to take a dosage of 100 to 200 mg every other day. This dosage is sufficient for a significant increase in strength and muscle mass. Men who prefer power sports, use it to increase strength, and bodybuilders in the process of active drying of the body. Testosterone propionate gives a greater effect when used in combination with other AAS, for example, methanolone, boldenone, nandrolone. For dry weight and strength, this drug is recommended for use with trenbolone or turinabol, while stanozolol, used in conjunction with a course of propionate, can cause joint problems. Propionate is well combined with oxandrolone, primobol or phenylpropinoate.

Side effects

In men, side effects when using testosterone can manifest itself in the form of baldness on the head, increased growth of hair on the body and face, greasiness of the skin, acne. Other side effects may manifest in the form of increased sexual arousal, frequent erections, increased libido, swelling, hypercalcemia, nausea and dizziness. Also, side effects include the possible development of cholestatic jaundice, thrombophlebitis, an increase in the level of aminotransferases, pain at the injection site, redness and itching. Predisposed to gynecomastia, may take on the course along with testosterone propionate tamoximed and / or proviron. As propionate ether has a negative impact on the development of its testosterone and reduces it, and in order to avoid a decline in the result, in this regard, it is recommended.

In women, side effects may appear in the form of masculinization: increased growth of hair on the body and face, coarsening of the voice, minor swelling of the skin.

In adolescents, side effects when using testosterone can manifest itself in the form of premature closure of the epiphyses of bones and premature puberty with an increase in the size of the genital organs.

Indications for use

Testosterone propionate is recommended to be used as an anabolic agent for the treatment of pathological conditions in which the protein is strongly disintegrated. These include severe injuries, surgical interventions, chronic infectious diseases, as well as malnutrition.

This drug is recommended for people of both sexes in the treatment of anemia, when etiotropic therapy is ineffective, in addition to it.

For men, testosterone propionate is recommended for use in substitution therapy for primary and secondary hypogonadism, eurychidism, post-stroke syndrome, impotence of endocrine genesis, men’s menopause, infertility that resulted from impaired spermatogenesis, osteoporosis caused by a lack of androgens, oligospermia, the initial stage of prostatic hypertrophy and acromegaly.

Women are recommended to use this drug for the treatment of hormone-dependent tumors, such as ovarian cancer, breast cancer; functional bleeding in hyperestrogenism; mastopathy, accompanied by painful exertion of the mammary glands in the premenstrual period; endometriosis, uterine fibroids. For the treatment of climacteric disorders apply in combination with estrogens

Contraindications for use

Testosterone propionate is not recommended for individual intolerance of the drug, prepubertal period in boys, women during breastfeeding and all trimesters of pregnancy, men of advanced age. It is also not recommended for violations of kidney or liver function, heart failure, prostate cancer, gynecomastia, severe asthenia, hypercalcemia.